12/9/2023 0 Comments Chromium benefits risksThe Panel noted that the margin of safety between the NOAEL of 2400 mg/kg bw/day chromium picolinate, resulting from the long-term study conducted by the NTP, equivalent to 2100 mg/kg bw picolinate/day would amount to at least four orders of magnitude assuming a combined intake of picolinate from all sources. Therefore the Panel concluded that a NOAEL could be established. They are rather common in the rat strain used. The incidences of preputial gland adenomas were not dose related and did not occur consistently across species, and not across sexes. From long-term carcinogenicity studies, it was concluded that there was equivocal evidence for the carcinogenic activity of chromium picolinate in male rats, and no evidence of carcinogenic activity of chromium picolinate in female rats, and female and male mice. The Panel noted that results of the new genotoxicity studies suggest that in vitro at high concentrations chromium picolinate might cause DNA damage. The Panel noted that specifications for chromium(III) picolinate should ensure that levels of chromium(VI) which is a genotoxic carcinogen are as low as possible and at least are such that they result in an adequate margin of exposure. Chromium picolinate is obtained synthetically. Competent organisations in Member Statesįollowing a request from the European Commission, the Panel on Food Additives and Nutrient Sources added to Food provides a scientific opinion on the safety of chromium picolinate as a source of chromium added for nutritional purposes to foodstuff for particular nutritional uses (PARNUTS) and to foods intended for the general population, and on the bioavailability of chromium from this source.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |